Targeting Nicotinamide N-Methyltransferase Overcomes Resistance to EGFR-TKI in Non-Small Cell Lung Cancer Cells

Using iTRAQ-based quantitative proteomics analysis, we identified that nicotinamide N-methyltransferase was significantly increased in epidermal growth factor receptor (EGFR)-tyrosine kinase inhibitor (TKI)-resistant NSCLC cells.