Ultrasound-assisted extract of yeast was found to effectively inhibit melanoma cell growth and proliferation as well as the expression of cyclin D1 and c-myc, in vitro.
Given the vast developments within this field, scientists review the wide-ranging and most current information related to pancreatic cancer genomics with the goal of integrating this information into a unifying description of the life history of pancreatic cancer.
[Nature Reviews Gastroenterology & Hepatology]
Single-cell-based approaches revealed striking temporal changes to the transcriptome and chromatin accessibility which have identified the emergence of distinct cell populations, marked by differential expression of Ascl1 and Pou2f3, during the transition to neuroendocrine prostate cancer.
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Scientists identified that TSN and RGF combination synergistically inhibited the proliferation and migration of MHCC-97L cells.
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Researchers investigated the relevance of the interactions between N-Myc and STAT Interactor protein (NMI) and various STATs to normal mammary development and cancer.
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Scientists clarified the role of KLHL38 in non-small cell lung cancer (NSCLC). KLHL38 expression was evaluated in tumor and adjacent normal tissues from 241 patients with NSCLC using immunohistochemistry and real-time PCR, and its association with clinicopathological parameters was analyzed.
[Cell Death & Disease]
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The authors utilized the established non-malignant HPr1-AR prostate epithelial cell model that upon androgen exposure committed to a luminal cell differentiation trajectory from that of a basal-like state.
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Scientists found that chronic exposure to antimony promoted cell growth and lipid metabolic disequilibrium in prostate cancer.
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Scientists demonstrated that local expression of the Yamanaka reprogramming factors, specifically in myofibers, induced the activation of muscle stem cells or satellite cells, which accelerated muscle regeneration in young mice.
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In each bladder cancer organoid strain, epidermal growth factor receptor/ERK signaling was upregulated compared with normal bladder cells.
[Cancer Biology & Therapy]
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Elbadawy, M., Sato, Y., Mori, T., Goto, Y., Hayashi, K., Yamanaka, M., Azakami, D., Uchide, T., Fukushima, R., Yoshida, T., Shibutani, M., Kobayashi, M., Shinohara, Y., Abugomaa, A., Kaneda, M., Yamawaki, H., Usui, T., & Sasaki, K. (2021). Anti-tumor effect of trametinib in bladder cancer organoid and the underlying mechanism. Cancer Biology & Therapy, 0(0), 1–15. https://doi.org/10.1080/15384047.2021.1919004 Cite
ALKBH5 gain- or loss-of function could effectively reverse LKB1 regulated cell proliferation, colony formation, and migration of KRAS-mutated lung cancer cells.
[Cell Death & Disease]
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Zhang, D., Ning, J., Okon, I., Zheng, X., Satyanarayana, G., Song, P., Xu, S., & Zou, M.-H. (2021). Suppression of m6A mRNA modification by DNA hypermethylated ALKBH5 aggravates the oncological behavior of KRAS mutation/LKB1 loss lung cancer. Cell Death & Disease, 12(6), 1–14. https://doi.org/10.1038/s41419-021-03793-7 Cite