Induced Pluripotent Stem Cells: Hope in the Treatment of Diseases, Including Muscular Dystrophies

iPSC cells are laboratory-produced cells that combine the biological advantages of somatic adult and stem cells for cell-based therapy. The reprogramming of cells, such as fibroblasts, to an ESC-like state is done by the ectopic expression of transcription factors responsible for generating embryonic stem cell properties.
[International Journal of Molecular Sciences]
Gois Beghini, D., Iwao Horita, S., Cascabulho, C. M., Anastácio Alves, L., & Henriques-Pons, A. (2020). Induced Pluripotent Stem Cells: Hope in the Treatment of Diseases, including Muscular Dystrophies. International Journal of Molecular Sciences, 21(15), 5467. https://doi.org/10.3390/ijms21155467 Cite
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Signatures of Co-deregulated Genes and Their Transcriptional Regulators in Colorectal Cancer

Researchers reanalyzed 19 GEO gene expression profiles to identify and annotate colorectal cancer versus normal signatures, single-gene perturbation, and single-drug perturbation signatures.
[npj Systems Biology and Applications]
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Signaling Input from Divergent Pathways Subverts B Cell Transformation

The authors analyzed 1,148 patient-derived B-cell leukemia samples, and found that individual mutations did not promote leukemogenesis unless they converged on one single oncogenic pathway that was characteristic of the differentiation stage of transformed B cells.
[Nature]
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TLR2/6 Signaling Promotes the Expansion of Premalignant Hematopoietic Stem and Progenitor Cells in the NUP98HOXD13 Mouse Model of MDS

Researchers tested the effects of specific modulation of Toll like receptor (TLR)1/2 versus TLR2/6 signaling on premalignant hematopoietic stem and progenitor cells.
[Experimental Hematology]
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A Novel TRPM7/O-GlcNAc Axis Mediates Tumor Cell Motility and Metastasis by Stabilising c-Myc and Caveolin-1 in Lung Carcinoma

Inhibition of TRPM7 suppressed cell motility in various non-small cell lung cancer cell lines and patient-derived primary cells and attenuated experimental lung metastases.
[British Journal of Cancer]
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Spermine Synthase and Myc Cooperate to Maintain Colorectal Cancer Cell Survival by Repressing Bim Expression

Researchers uncover a key survival signal in colorectal cancer through convergent repression of Bim expression by distinct SMS- and MYC-mediated signaling pathways.
[Nature Communications]
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