Selective Antisense Oligonucleotide Inhibition of Human IRF4 Prevents Malignant Myeloma Regeneration via Cell Cycle Disruption

Using diverse pre-clinical models, the authors investigated the role of interferon regulatory factor 4 (IRF4) in myeloma progenitor regeneration.
[Cell Stem Cell]
Selective antisense oligonucleotide inhibition of human IRF4 prevents malignant myeloma regeneration via cell cycle disruption: Cell Stem Cell. (n.d.). Retrieved January 21, 2021, from https://www.cell.com/cell-stem-cell/fulltext/S1934-5909(20)30601-9 Cite
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Selective Antisense Oligonucleotide Inhibition of Human IRF4 Prevents Malignant Myeloma Regeneration via Cell Cycle Disruption

Using diverse pre-clinical models, the authors investigated the role of interferon regulatory factor 4 (IRF4) in myeloma progenitor regeneration.
[Cell Stem Cell]
Mondala, P. K., Vora, A. A., Zhou, T., Lazzari, E., Ladel, L., Luo, X., Kim, Y., Costello, C., MacLeod, A. R., Jamieson, C. H. M., & Crews, L. A. (2021). Selective antisense oligonucleotide inhibition of human IRF4 prevents malignant myeloma regeneration via cell cycle disruption. Cell Stem Cell, 0(0). https://doi.org/10.1016/j.stem.2020.12.017 Cite
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Epidermal Progenitors Suppress GRHL3-Mediated Differentiation through Intronic Polyadenylation Promoted by CPSF-HNRNPA3 Collaboration

Scientists showed that hundreds of intronic polyadenylation sites were differentially used during keratinocyte differentiation, which was accompanied by downregulation of the Cleavage and Polyadenylation Specificity Factor (CPSF) complex.
[Nature Communications]
Chen, X., Lloyd, S. M., Kweon, J., Gamalong, G. M., & Bao, X. (2021). Epidermal progenitors suppress GRHL3-mediated differentiation through intronic polyadenylation promoted by CPSF-HNRNPA3 collaboration. Nature Communications, 12(1), 448. https://doi.org/10.1038/s41467-020-20674-3 Cite
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A Novel Hypoxic Long Noncoding RNA KB-1980E6.3 Maintains Breast Cancer Stem Cell Stemness via Interacting With IGF2BP1 to Facilitate C-Myc mRNA Stability

The enhanced long noncoding RNA KB-1980E6.3 facilitated breast cancer stem cells self-renewal and tumorigenesis under hypoxic microenvironment both in vitro and in vivo.
[Oncogene]
Zhu, P., He, F., Hou, Y., Tu, G., Li, Q., Jin, T., Zeng, H., Qin, Y., Wan, X., Qiao, Y., Qiu, Y., Teng, Y., & Liu, M. (2021). A novel hypoxic long noncoding RNA KB-1980E6.3 maintains breast cancer stem cell stemness via interacting with IGF2BP1 to facilitate c-Myc mRNA stability. Oncogene, 1–19. https://doi.org/10.1038/s41388-020-01638-9 Cite
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Histone Demethylase KDM4C Controls Tumorigenesis of Glioblastoma by Epigenetically Regulating p53 and C-Myc

Researchers showed that KDM4C knockdown significantly repressed proliferation and tumorigenesis of glioblastoma cells in vitro and in vivo that were rescued by overexpressing wild-type KDM4C but not a catalytic dead mutant.
[Cell Death & Disease]
Lee, D. H., Kim, G. W., Yoo, J., Lee, S. W., Jeon, Y. H., Kim, S. Y., Kang, H. G., Kim, D.-H., Chun, K.-H., Choi, J., & Kwon, S. H. (2021). Histone demethylase KDM4C controls tumorigenesis of glioblastoma by epigenetically regulating p53 and c-Myc. Cell Death & Disease, 12(1), 1–14. https://doi.org/10.1038/s41419-020-03380-2 Cite
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Overcoming Hypoxia-Induced Resistance of Pancreatic and Lung Tumor Cells by Disrupting the PERK-NRF2-HIF-Axis

Scientists generated human cancer cell lines of pancreatic and lung origin carrying an inducible shRNA against NRF2 and PERK. They report that PERK-related phosphorylation of NRF2 was only critical in Keap1 wildtype cells to escape its degradation, but showed no direct effect on nuclear import or transcriptional activity of NRF2.
[Cell Death & Disease]
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Spliceosome-Targeted Therapies Trigger an Antiviral Immune Response in Triple-Negative Breast Cancer

Scientists discovered that mis-spliced RNA itself is a molecular trigger for tumor killing through viral mimicry. In MYC-driven TNBC, spliceosome-targeted therapies caused widespread cytoplasmic accumulation of mis-spliced mRNAs, many of which form double-stranded structures.
[Cell]
Bowling, E. A., Wang, J. H., Gong, F., Wu, W., Neill, N. J., Kim, I. S., Tyagi, S., Orellana, M., Kurley, S. J., Dominguez-Vidaña, R., Chung, H.-C., Hsu, T. Y.-T., Dubrulle, J., Saltzman, A. B., Li, H., Meena, J. K., Canlas, G. M., Chamakuri, S., Singh, S., … Westbrook, T. F. (2021). Spliceosome-targeted therapies trigger an antiviral immune response in triple-negative breast cancer. Cell, 0(0). https://doi.org/10.1016/j.cell.2020.12.031 Cite
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ALK Ligand ALKAL2 Potentiates MYCN-Driven Neuroblastoma in the Absence of ALK Mutation

Scientists tested whether anaplastic lymphoma kinase AL2 (ALKAL2) ligand could potentiate neuroblastoma progression in the absence of ALK mutation
[EMBO Journal]
Borenäs, M., Umapathy, G., Lai, W.-Y., Lind, D. E., Witek, B., Guan, J., Mendoza-Garcia, P., Masudi, T., Claeys, A., Chuang, T.-P., El Wakil, A., Arefin, B., Fransson, S., Koster, J., Johansson, M., Gaarder, J., Van den Eynden, J., Hallberg, B., & Palmer, R. H. (2021). ALK ligand ALKAL2 potentiates MYCN-driven neuroblastoma in the absence of ALK mutation. The EMBO Journal, n/a(n/a), e105784. https://doi.org/10.15252/embj.2020105784 Cite
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Piwil1 Regulates Glioma Stem Cell Maintenance and Glioblastoma Progression

Researchers report that Piwi-like family members were overexpressed in glioblastoma, with Piwil1 most frequently overexpressed. Piwil1 was enriched in glioma stem-like cells to maintain self-renewal.
[Cell Reports]
Huang, H., Yu, X., Han, X., Hao, J., Zhao, J., Bebek, G., Bao, S., Prayson, R. A., Khalil, A. M., Jankowsky, E., & Yu, J. S. (2021). Piwil1 Regulates Glioma Stem Cell Maintenance and Glioblastoma Progression. Cell Reports, 34(1). https://doi.org/10.1016/j.celrep.2020.108522 Cite
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Identification of PIM1 Substrates Reveals a Role for NDRG1 Phosphorylation in Prostate Cancer Cellular Migration and Invasion

Investigators performed a direct, unbiased chemical genetic screen to identify pro-viral integration site for Moloney murine leukemia virus-1 (PIM1) substrates in prostate cancer cells.
[Communications Biology]
Ledet, R. J., Ruff, S. E., Wang, Y., Nayak, S., Schneider, J. A., Ueberheide, B., Logan, S. K., & Garabedian, M. J. (2021). Identification of PIM1 substrates reveals a role for NDRG1 phosphorylation in prostate cancer cellular migration and invasion. Communications Biology, 4(1), 1–12. https://doi.org/10.1038/s42003-020-01528-6 Cite
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Deciphering the Genomic and lncRNA Landscapes of Aerobic Glycolysis Identifies Potential Therapeutic Targets in Pancreatic Cancer

Integrated analysis of transcriptional profiles revealed many differentially expressed long non-coding RNAs involved in PDAC aerobic glycolysis.
[International Journal of Biological Sciences]
Zhu, L.-L., Wu, Z., Li, R.-K., Xing, X., Jiang, Y.-S., Li, J., Wang, Y.-H., Hu, L.-P., Wang, X., Qin, W.-T., Sun, Y.-W., Zhang, Z.-G., Yang, Q., & Jiang, S.-H. (2021). Deciphering the genomic and lncRNA landscapes of aerobic glycolysis identifies potential therapeutic targets in pancreatic cancer. International Journal of Biological Sciences, 17(1), 107–118. https://doi.org/10.7150/ijbs.49243 Cite
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