Tag Archives: NSCLC

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Secretoglobin 3A2 Eliminates Human Cancer Cells through Pyroptosis

Researchers showed that secretoglobin 3A2 exhibits marked anti-cancer activity against 5 out of 11 of human non-small cell lung cancer cell lines in mouse xenographs, while no effect was observed in 6 of 6 small cell lung cancer cell lines examined.

[Cell Death Discovery]

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Nrf2 Regulates Cell Motility through RhoA–ROCK1 Signaling in Non-Small-Cell Lung Cancer Cells

Researchers observed that nuclear factor-erythroid 2-related factor 2 (Nrf2) suppression following treatment with brusatol in non-small-cell lung cancer cells with either exogenously introduced kelch-like ECH-associated protein 1 or siNrf2 resulted in the inhibition of cell migration and invasion, with shrinking cell morphology due to decreased focal adhesions via inhibition of the RhoA–ROCK1 pathway.

[Scientific Reports]

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circNDUFB2 Inhibits Non-Small Cell Lung Cancer Progression via Destabilizing IGF2BPs and Activating Anti-Tumor Immunity

Researchers identified circNDUFB2 to be downregulated in non-small cell lung cancer (NSCLC) tissues, and to negatively correlate with NSCLC malignant features.

[Nature Communications]

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Polysaccharide Hydrogel Based 3D Printed Tumor Models for Chemotherapeutic Drug Screening

Results of flow property, shape fidelity, scaffold stability and biocompatibility of H4-RGD suggest that the proposed hydrogel could be considered for 3D cell bioprinting and also for in vitro tumor microenvironment development for high throughput screening of various anti-cancer drugs.

[Scientific Reports]

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ACPA Decreases Non-Small Cell Lung Cancer Line Growth through Akt/PI3K and JNK Pathways In Vitro

Investigators confirmed that CB1 receptor (CB1R) was expressed in non-small cell lung cancer cells in this study. Arachidonoylcyclopropylamide (ACPA) as a synthetic, CB1R-specific ligand decreased proliferation rate in NSCLC cells by WST-1 analysis and real-time proliferation assay.

[Cell Death & Disease]

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CXCR4 Uses STAT3-Mediated Slug Expression to Maintain Radioresistance of Non-Small Cell Lung Cancer Cells: Emerges as a Potential Prognostic Biomarker for Lung Cancer

Researchers inferred that CXCR4 confers resistance to ionizing radiation (IR) in nonsmall cell lung cancer cells. Further, on the basis of colony forming ability, they found that drug-resistant A549/GR cells with improved CXCR4 expression exhibited more resistance to IR than A549 cells evidenced along with a reduction in the formation of γ-H2AX foci after IR.

[Cell Death & Disease]

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Restored MicroRNA-519a Enhances the Radiosensitivity of Non-Small Cell Lung Cancer via Suppressing EphA2

Researchers investigated the role of miR-519a-targeted ephrinA2 receptor in radiosensitivity of NSCLC. miR-519a and EphA2 expression in non-small cell lung cancer and paracancerous tissues were detected using RT-qPCR and western blot analysis.

[Gene Therapy]

Abstract

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industry & policy

Genentech’s Novel Anti-TIGIT Tiragolumab Granted FDA Breakthrough Therapy Designation in Combination with Tecentriq for PD-L1-High Non-Small Cell Lung Cancer

Genentech announced that tiragolumab, a novel cancer immunotherapy designed to bind to TIGIT, has been granted Breakthrough Therapy Designation by the FDA, in combination with Tecentriq^® for the first-line treatment of people with metastatic non-small cell lung cancer whose tumors have high PD-L1 expression with no EGFR or ALK genomic tumor aberrations.

[Genentech]

Press Release

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ZCCHC14 Regulates Proliferation and Invasion of Non–Small Cell Lung Cancer through the MAPK‐P38 Signaling Pathway

The authors explored the expression, function and related molecular mechanisms of ZCCHC14 in human non-small cell lung cancer.

[Journal of Cellular and Molecular Medicine]

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Exosomal miR‐3180‐3p Inhibits Proliferation and Metastasis of Non‐Small Cell Lung Cancer by Downregulating FOXP4

Researchers found that miR‐3180‐3p decreased in both non‐small cell lung cancer (NSCLC) cell lines and patient tissues. Overexpression of miR‐3180‐3p or treatment with exosomal miR‐3180‐3p significantly suppressed cell proliferation and metastasis in NSCLC cell lines.

[Thoracic Cancer]