GAS6-AS2 was identified, and its roles as well as mechanisms in regulating proliferation of non-small cell lung cancer cells were investigated.
Researchers showed that secretoglobin 3A2 exhibits marked anti-cancer activity against 5 out of 11 of human non-small cell lung cancer cell lines in mouse xenographs, while no effect was observed in 6 of 6 small cell lung cancer cell lines examined.
[Cell Death Discovery]
Researchers observed that nuclear factor-erythroid 2-related factor 2 (Nrf2) suppression following treatment with brusatol in non-small-cell lung cancer cells with either exogenously introduced kelch-like ECH-associated protein 1 or siNrf2 resulted in the inhibition of cell migration and invasion, with shrinking cell morphology due to decreased focal adhesions via inhibition of the RhoA–ROCK1 pathway.
Researchers identified circNDUFB2 to be downregulated in non-small cell lung cancer (NSCLC) tissues, and to negatively correlate with NSCLC malignant features.
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Results of flow property, shape fidelity, scaffold stability and biocompatibility of H4-RGD suggest that the proposed hydrogel could be considered for 3D cell bioprinting and also for in vitro tumor microenvironment development for high throughput screening of various anti-cancer drugs.
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Gebeyehu, A., Surapaneni, S. K., Huang, J., Mondal, A., Wang, V. Z., Haruna, N. F., Bagde, A., Arthur, P., Kutlehria, S., Patel, N., Rishi, A. K., & Singh, M. (2021). Polysaccharide hydrogel based 3D printed tumor models for chemotherapeutic drug screening. Scientific Reports, 11(1), 372. https://doi.org/10.1038/s41598-020-79325-8 Cite
Investigators confirmed that CB1 receptor (CB1R) was expressed in non-small cell lung cancer cells in this study. Arachidonoylcyclopropylamide (ACPA) as a synthetic, CB1R-specific ligand decreased proliferation rate in NSCLC cells by WST-1 analysis and real-time proliferation assay.
[Cell Death & Disease]
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Researchers inferred that CXCR4 confers resistance to ionizing radiation (IR) in nonsmall cell lung cancer cells. Further, on the basis of colony forming ability, they found that drug-resistant A549/GR cells with improved CXCR4 expression exhibited more resistance to IR than A549 cells evidenced along with a reduction in the formation of γ-H2AX foci after IR.
[Cell Death & Disease]
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Researchers investigated the role of miR-519a-targeted ephrinA2 receptor in radiosensitivity of NSCLC. miR-519a and EphA2 expression in non-small cell lung cancer and paracancerous tissues were detected using RT-qPCR and western blot analysis.
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Genentech announced that tiragolumab, a novel cancer immunotherapy designed to bind to TIGIT, has been granted Breakthrough Therapy Designation by the FDA, in combination with Tecentriq® for the first-line treatment of people with metastatic non-small cell lung cancer whose tumors have high PD-L1 expression with no EGFR or ALK genomic tumor aberrations.
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The authors explored the expression, function and related molecular mechanisms of ZCCHC14 in human non-small cell lung cancer.
[Journal of Cellular and Molecular Medicine]
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Researchers found that miR‐3180‐3p decreased in both non‐small cell lung cancer (NSCLC) cell lines and patient tissues. Overexpression of miR‐3180‐3p or treatment with exosomal miR‐3180‐3p significantly suppressed cell proliferation and metastasis in NSCLC cell lines.
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