Hexokinase 2-Driven Glycolysis in Pericytes Activates Their Contractility Leading to Tumor Blood Vessel Abnormalities

The authors developed a method that combines magnetic beads and flow cytometry cell sorting to isolate pericytes from tumors and normal adjacent tissues from patients with non-small cell lung cancer and hepatocellular carcinoma.
[Nature Communications]
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An SETD1A/Wnt/β-Catenin Feedback Loop Promotes NSCLC Development

Researchers found that SETD1A positively regulated the Wnt/β-catenin pathway via interacting with and stabilizing β-catenin.
[Journal of Experimental & Clinical Cancer Research]
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Potentiated Lung Adenocarcinoma (LUAD) Cell Growth, Migration and Invasion by lncRNA DARS-AS1 via miR-188-5p/ KLF12 Axis

Cell functional experiments revealed that lncRNA DARS-AS1 participated in enhancing lung adenocarcinoma proliferation, invasion, and migration by inhibiting miR-188-5p.
[Aging]
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Treating Disease Progression with Osimertinib in EGFR-Mutated Non-Small Cell Lung Cancer: Novel Targeted Agents and Combination Strategies

In this review, the post-osimertinib treatment options for EGFR-mutated non-small-cell lung cancer are analyzed, with an outlook to ongoing clinical trials.
[ESMO Open]
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MYH9 Is Crucial for Stem Cell-Like Properties in Non-Small Cell Lung Cancer by Activating mTOR Signaling

The authors found that the stemness characteristics of lung cancer cells were significantly enhanced by the overexpression of non-muscle myosin heavy chain 9 (MYH9), and the knockout of MYH9 had the opposite effects.
[Cell Death Discovery]
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M6A RNA Methylation-Mediated RMRP Stability Renders Proliferation and Progression of Non-Small Cell Lung Cancer through Regulating TGFBR1/SMAD2/SMAD3 Pathway

Based on an integrative analysis of The Cancer Genome Atlas database, investigators identified long non-coding RNA-RNA Component of Mitochondrial RNA Processing Endoribonuclease (RMRP) as one of the most highly upregulated lncRNAs that are associated with poor survival in non-small cell lung cancer.
[Cell Death & Differentiation]
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Evolution of MET and NRAS Gene Amplification as Acquired Resistance Mechanisms in EGFR Mutant NSCLC

A patient-derived cell line obtained at the time of disease progression was used to identify NRAS gene amplification as an additional driver of drug resistance to combination EGFR/MET therapies.
[npj Precision Oncology]
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Three Subtypes of Lung Cancer Fibroblasts Define Distinct Therapeutic Paradigms

By functionally interrogating cancer-associated fibroblasts heterogeneity using the same therapeutics received by patients, the authors identified three functional subtypes: robustly protective of cancers and highly expressing HGF and FGF7; moderately protective of cancers and highly expressing FGF7; and those providing minimal protection.
[Cancer Cell]
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Soluble PD-L1 Is a Predictive and Prognostic Biomarker in Advanced Cancer Patients Who Receive Immune Checkpoint Blockade Treatment

Researchers investigated the significance of sPD-L1 in cancer patients receiving immune checkpoint inhibitor therapy.
[Scientific Reports]
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Contribution of p53 in Sensitivity to EGFR Tyrosine Kinase Inhibitors in Non-Small Cell Lung Cancer

Researchers investigated the effects of p53 in primary sensitivity and acquired resistance to EGFR-TKIs in NSCLC cells.
[Scientific Reports]
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Autophagic Secretion of HMGB1 from Cancer-Associated Fibroblasts Promotes Metastatic Potential of Non-Small Cell Lung Cancer Cells via NFκB Signaling

Researchers reported that autophagy was upregulated in lung cancer-associated cancer-associated fibroblasts (CAFs) compared to normal fibroblasts, and autophagy was responsible for the promoting effect of CAFs on non-small cell lung cancer cell migration and invasion.
[Cell Death & Disease]
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