EMT

[Translational Oncology] Investigators suggested that stiffer substrate enhanced melanoma development by upregulating SNF5 expression, and SNF5 was a key mediator of stiffer matrix-induced immune evasion of melanoma cancer cells.

[Cell Death & Disease] Researchers identified neurokinin-1 as a significantly upregulated GPCR in the transcriptome and tissue array of human lung cancer samples, associated with advanced clinical stages and poor prognosis.

[Molecular Cancer] Hsa_circ_0003258 physically binded to insulin like growth factor 2 mRNA binding protein 3 (IGF2BP3) in the cytoplasm and enhanced HDAC4 mRNA stability, in which it activated ERK signaling pathway, then triggered epithelial mesenchymal transformation programming and finally accelerated the metastasis of prostate cancer.

[Cellular Signalling] Scientists analyzed Clinical Proteomic Tumor Analysis Consortium, colon tissue microarray, and colon cancer cells to evaluate the ESRP1 expression levels in colorectal cancer subtypes.

[Journal of Cellular Biochemistry] To investigate the function of factor binding inducer of short transcripts-1 (FBI-1) in epithelial-to-mesenchymal transition (EMT) in lung cancer, EMT was measured in FBI-1-deficient or FBI-1-overexpressing cells.

[Cell Biology International] HPV16 E6 silence or overexpression were carried out to evaluate the possible mechanisms of HPV16 E6 function in cervical cancer cells with different HPV16 E6 expression background.