EMT

[Journal of Biological Research-Thessaloniki] Investigators used Prx6 overexpressed and downregulated HCT116 cells to study the mechanism between Prx6 and colon cancer.

[Molecular Carcinogenesis] Scientists found that NUAK family kinase 2 (NUAK2) expression was elevated in prostate cancer and metastatic castration resistant PC versus normal tissue, and expression correlated with an increased risk of metastasis.

[Cell Reports] Researchers found that F-box and leucine-rich repeat protein 16 (FBXL16) acted as a tumor suppressor in TNBCs. FBXL16 directly bound to HIF1α and induced its ubiquitination and degradation, regardless of the tumor microenvironment, resulting in angiogenesis features of breast cancer.

[Science Signaling] Researchers found that primary human adipocytes shed extracellular vesicles, specifically exosomes, that induced the expression of genes associated with epithelial-to-mesenchymal transition and cancer stem–like cell traits in cocultured breast cancer cell lines.

[Experimental Cell Research] Researchers investigated the effects of Ad-apoptin on glycolysis, migration and invasion of non-small cell lung cancer.

[Acta Pharmacologica Sinica] The authors demonstrated that 5-(4-hydroxyphenyl)−3H-1,2-dithiocyclopentene-3-thione (ADT-OH) inhibited the EMT process in melanoma cells by suppressing the CSE/CBS and FAK signaling pathways, thereby exerting its antimetastatic activity.