EMT

[Scientific Reports] Scientists reported the antitumor effects and mechanism of a novel benzothiazole derivative 4-methoxy-cyclohexane carboxylic acid [2-(3,5-dimethyl-isoxazole-4-yl) sulpanil-benzothiazole-6-yl]-amide (PB01) in radiation-resistant human non-small-cell lung cancer cells.

[Scientific Reports] The authors used preclinical experimental models to investigate whether an inactive form of receptor activator of nuclear factor kappa-B ligand (RANKL) affected bone metastasis in RANKL-induced prostate cancer.

[Molecular Therapy-Nucleic Acids] The effects of conditioned medium collected from dedifferentiated adipocytes on pancreatic cancer cell proliferation, motility, metastasis and epithelial-mesenchymal transition (EMT) were evaluated by western blot analysis, colony forming, real-time cell analysis, 5-ethynyl-2’-deoxyuridine, immunofluorescence, Transwell and wound healing assays in vitro.

[Scientific Reports] Scientists studied the biological function of cytoplasmic maspin in breast cancer cell lines. Subcellular localization of maspin in MDA-MB-231 breast cancer cells was mainly detected in the cytoplasm, whereas in MCF10A mammary epithelial cells, maspin was present in both cytoplasm and nucleus.

[Oncogene] Scientists found that Lnc-408, a novel long noncoding RNA, was significantly upregulated in breast cancer (BC) cells undergoing epithelial-mesenchymal transformation and in BC tumor with lymphatic metastases compared with those without lymphatic metastases.

[Scientific Reports] Using an in vitro model of epithelial to mesenchymal transition (EMT), investigators showed that nitrofen interfered with the process of EMT and promoted mesenchymal to epithelial transformation.