Role of Cytoplasmic Localization of Maspin in Promoting Cell Invasion in Breast Cancer with Aggressive Phenotype

Scientists studied the biological function of cytoplasmic maspin in breast cancer cell lines. Subcellular localization of maspin in MDA-MB-231 breast cancer cells was mainly detected in the cytoplasm, whereas in MCF10A mammary epithelial cells, maspin was present in both cytoplasm and nucleus.