ERK2

[Molecular Cancer Research] Investigators demonstrated that ERK2 drove BRAF-mutant melanoma gene expression and proliferation as a function of its higher expression compared to ERK1.

[Autophagy] Researchers showed that ULK1 deficiency induced an invasive phenotype of breast cancer cells under hypoxia and increases osteolytic bone metastasis.

[Oncogene] Investigators utilized a 3D co-culture model incorporating estrogen receptor-positive breast cancer cells and bone marrow mesenchymal stem cells to represent disseminated tumors cells in a bone marrow niche.

[Proceedings of the National Academy of Sciences of the United States of America] This study showed that exit from the stem cell compartment in mammalian epidermis was characterized by pulsatile ERK MAPK activity.