MAPK1/3 Kinase-Dependent ULK1 Degradation Attenuates Mitophagy and Promotes Breast Cancer Bone Metastasis

By
Justin.choi
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Researchers showed that ULK1 deficiency induced an invasive phenotype of breast cancer cells under hypoxia and increases osteolytic bone metastasis.
[Autophagy]
Deng, R., Zhang, H.-L., Huang, J.-H., Cai, R.-Z., Wang, Y., Chen, Y.-H., Hu, B.-X., Ye, Z.-P., Li, Z.-L., Mai, J., Huang, Y., Li, X., Peng, X.-D., Feng, G.-K., Li, J.-D., Tang, J., & Zhu, X.-F. (2020). MAPK1/3 kinase-dependent ULK1 degradation attenuates mitophagy and promotes breast cancer bone metastasis. Autophagy, 0(ja), null. https://doi.org/10.1080/15548627.2020.1850609 Cite
Abstract