Fos

[Biochemical and Biophysical Research Communications] Scientists applied single-cell RNA sequencing and single-cell sequencing assay for transposase-accessible chromatin to systematically profile umbilical cord blood nucleated cells and peripheral blood mononuclear cells to identify their composition and differentially expressed genes.

[Science Signaling] In cultured oral epithelial cells, candidalysin activated the MAPK p38, which resulted in heat shock protein 27 (Hsp27) activation, IL-6 release, and EGFR phosphorylation without affecting the induction of c-Fos.

[Cell Death & Disease] Scientists found that linc01133 was significantly upregulated in gastric cancer tissues compared to non-tumorous gastric tissues. Linc01133 over-expression significantly correlated with tumor size and tumor differentiation in gastric cancer patients.

[Frontiers in Immunology] According to large-scale single-cell analysis, recovered patients, who had severe symptoms, still exhibited peripheral immune disorders one-two months after symptom onset.

[Hepatology] Scientists identified interferon regulatory factor (IRF8) as an important prognostic biomarker in hepatocellular carcinoma patients which predicted the response and sensitivity to anti-PD-1 therapy.

[Bioengineered] Scientists constructed prostate-specific membrane antigen (PSMA)-knockdown LNCaP and 22rv1 cell lines and performed metabonomic and transcriptomic analyses to determine the effects of PSMA on prostate cancer metabolism and transcription.