GFAP

[American Journal of Physiology-Gastrointestinal and Liver Physiology] Scientists investigated the effect of Gli2 on liver fibrogenesis and its possible mechanism using conditional knockout Gli2 mice and hepatic stellate cell models.

[Gene Therapy] Scientists used adeno-associated virus to deliver CRISPR/guide RNA designed to abolish the genes NeuN, GFAP, or MOG expressed specifically in neurons, astrocytes, or oligodendrocytes respectively in the central nervous system of mice.

[Tissue Engineering and Regenerative Medicine] The differentiation of Wharton jelly (WJ)-MSCs into Schwann cell-like cells was determined by analyzing Schwann cell-specific markers. The secretion of neurotrophic factors was assessed by the Neuro Discovery antibody array.

[Journal of Pain Research] Researchers developed an alginate scaffold with human umbilical cord mesenchymal stem cell exosomes to treat nerve injury-induced pain. In vitro studies of PC12 and HEK293 cells were used to evaluate the neuroprotective and neurotrophic effects of exosomes.

[Cell Death Discovery] Many studies demonstrated that fibroblast growth factor therapies after spinal cord injury (SCI) could be used in the future for the recovery of neurons. The therapeutic effects of gelatine nanostructured lipid carriers-encapsulated fibroblast growth factor 15 (FGF15) and FGF15 were compared in SCI.

[Scientific Reports] The authors studied the effects of Hyaluronic acid (HA) content as a key regulator of human astrocyte reactivity using mIPNs comprised of Collagen I, HA and poly(ethylene glycol) diacrylate.