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Pulmonary Cell NewsScientists used adeno-associated virus to deliver CRISPR/guide RNA designed to abolish the genes NeuN, GFAP, or MOG expressed specifically in neurons, astrocytes, or oligodendrocytes respectively in the central nervous system of mice.
[Gene Therapy]
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Torregrosa, T., Lehman, S., Hana, S., Marsh, G., Xu, S., Koszka, K., Mastrangelo, N., McCampbell, A., Henderson, C. E., & Lo, S.-C. (2021). Use of CRISPR/Cas9-mediated disruption of CNS cell type genes to profile transduction of AAV by neonatal intracerebroventricular delivery in mice. Gene Therapy, 1–13. https://doi.org/10.1038/s41434-021-00223-3 Cite
