GWAS

[Nature Communications] Scientists showed that Alzheimer’s disease risk alleles were specifically enriched in active enhancers of monocytes, macrophages and microglia.

[Laboratory Investigation] Initiation of a Barrett’s esophagus-like metaplastic change was evaluated by measuring characteristic cytokeratins and global gene expression profiling and by culturing organoids.

[Nature] Scientists report the results of the Genetics Of Mortality In Critical Care genome-wide association study in 2244 critically ill Covid-19 patients from 208 UK intensive care units.

[Science Advances] Researchers generated transcriptome (RNA-seq), epigenome (ChIP-seq of H3K27ac, H3K4me1, and H3K4me3 histone modifications), open chromatin (ATAC-seq), and chromatin interaction (promoter capture Hi-C) annotations of cultured primary decidua-derived MSCs and in vitro differentiated decidual stromal cells and developed a computational framework to integrate these functional annotations with results from a GWAS of gestational duration in 56,384 women.

[Communications Biology] Scientists demonstrated that cultured primary bronchial epithelial cells from adults with asthma showed different transcriptional and chromatin responses to rhinovirus infection compared to those without asthma.

[Translational Psychiatry] Quantitative proteomics revealed NLRP2 as the most significantly up-regulated protein in neural stem cells and mature neural cells obtained from bipolar disorder-patient cell samples.