H3K27

[Genome Research] Investigators used a mESC model to describe in detail the relationships within the H3K27-H3K36-DNA methylation subnetwork, with a focus on the major epigenetic reorganization caused by deletion of the histone 3 lysine 36 methyltransferase NSD1, which in mESCs deposits nearly all of the intergenic H3K36me2.

[Nature] The authors devised a screening strategy and identified small molecules that bound the non-coding RNA prototype Xist.

[Cancer Discovery] In models of AML, leukemia cell differentiation and therapeutic benefit mediated by the histone deacetylases inhibitor panobinostat required activation of the type I interferon pathway.

[Genome Research] Together with information from genome-wide association studies or vascular disease traits, scientists tested the ability of 34,344 variants to perturb enhancer function in endothelial cells using the highly multiplexed STARR-seq assay.

[Nature Communications] The authors demonstrated an intricate balance between androgen receptor and MYC, and indicated that increased MYC in response to androgen deprivation contributes to CRPC, while decreased MYC may contribute to responses to supraphysiological androgen therapy.

[Nature Communications] Hepatocyte-specific deletion of Mettl3 drove nonalcoholic fatty liver-to-NASH progression by increasing CD36-mediated hepatic free fatty acid uptake and CCL2-induced inflammation, which is due to increased chromatin accessibility in the promoter region of Cd36 and Ccl2.