HIF

[Gut] Scientists elucidated the nature, regulation and functional relevance of PD-L1+ host cells in HCC.

[Oncogene] Researchers reported that phenazine biosynthesis-like domain-containing protein (PBLD) inhibited hypoxia-induced angiogenesis via ERK/HIF-1a/VEGF axis in HCC cells.

[Oncogene] Phenazine biosynthesis-like domain-containing protein (PBLD) exerted an inhibitory effect on angiogenesis not only via blocking the VEGFR2 expression in endothelial cells, but also through downregulating HIF-1a-induced VEGF expression and secretion in hepatocellular carcinoma cells.

[Molecular Therapy Oncolytics] Scientists explored the biological function of circSHKBP1 in NSCLC. CircSHKBP1 was found to be upregulated in NSCLC tissues and cell lines and was enriched in exosomes derived from NSCLC cells.

[Cell Death & Disease] The authors identified a HCC-related lncRNA, CMB9-22P13.1, which was highly expressed and correlated with advanced stage, vascular invasion, and poor survival in HCC.

[Science Translational Medicine] Researchers demonstrated a mechanism of HSC malignant transformation through altered energy metabolism and provided a potential therapeutic strategy to treat patients with AML.