HIF

[Scientific Reports] Researchers investigated the potential of CSC differentiation into blood cells under chemical hypoxic conditions using CoCl2. CSCs and miPS-LLCcm cells were cultured for one to seven days in the presence of CoCl2, and the expression of VEGFR1/2, Runx1, c-kit, CD31, CD34, and TER-119 was assessed by RT-qPCR, Western blotting and flow cytometry together with Wright-Giemsa staining and immunocytochemistry.

[iScience] Scientists showed that miR-29cb2 was a bone-specific miRNA and played critical roles on angiogenesis-osteogenesis coupling during bone remodeling.

[Current Biology] Hypoxia-induced amoeboid dissemination occurred through low ECM-adhesive, predominantly bleb-based amoeboid movement, which was maintained by a low-oxidative and -glycolytic energy metabolism.

[Stem Cells International] Scientists identified the preventative defensive ability and therapeutic effect of human umbilical cord mesenchymal stem cells (HUCMSCs). HUCMSCs were administered before or after bleomycin injection in different groups of C57BL/6 mice.

[Aging] The tumor-suppressive effects of puerarin were determined by both in vitro and in vivo assays. The effects of puerarin on the proliferation, apoptosis, migration and invasion of pancreatic cancer cells, and tumor growth and metastasis in pancreatic ductal adenocarcinoma xenograft mouse model were performed.

[Cell Proliferation] Scientists investigate the functional role of hepatic stellate cell ferroptosis in the anti-fibrotic effect of sorafenib and found that sorafenib attenuated liver injury and extracellular matrix accumulation in CCl4-induced fibrotic livers, accompanied by reduction of SLC7A11 and GPX4 proteins.