IL-6

[Experimental & Molecular Medicine] Researchers identified and functionally validated a long noncoding RNAs using human atherosclerotic plaques. Human aortic samples were obtained from patients who underwent aortic surgery, and tissues were classified according to atherosclerotic plaques.

[Biochemical Pharmacology] Luxeptinib inhibited the release of three cytokines from THP-1 monocytes and macrophages at concentrations of 0.1 µM and above.

[Disease Models & Mechanisms] Researchers elaborate on a bi-phasic effect of gelatin in skeletal muscle regeneration, mediated by hormetic effects of reactive oxygen species.

[Journal of Investigative Dermatology] Researchers investigated the potential contribution of LIGHT to systemic sclerosis (SSc) development using clinical samples and animal models. In SSc-involved skin, LIGHT was up-regulated in inflammatory cells, while HVEM, a receptor of LIGHT, was down-regulated in dermal fibroblasts.

[Histochemistry and Cell Biology] Scientists focused on potential differences in the activity of exosomes produced by melanoma cells towards melanoma-associated fibroblasts and normal dermal fibroblasts. They demonstrated that melanoma-produced exosomes significantly stimulated the tumor-promoting proinflammatory activity of cancer-associated fibroblasts.

[Nature Reviews Disease Primers] VEGF is a potent angiogenic factor that may have a role in the pathogenesis of the Kaposi sarcoma herpesvirus (KSHV)-negative idiopathic form of multicentric Castelman disease (MCD) and KSHV-MCD, as endothelial cell and blood vessel proliferation is an important component of MCD.