The BXD21/TyJ Recombinant Inbred Strain as a Model for Innate Inflammatory Response in Distinct Brain Regions

Scientists determined whether BXD recombinant inbred mice strains were more suitable than C57BL/6J mice for the understanding of the relationship between antioxidant response and inflammatory responses.
[Scientific Reports]
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Suppressive Myeloid Cells Are Expanded by Biliary Tract Cancer-Derived Cytokines In Vitro and Associate with Aggressive Disease

Activated signaling pathways and cytokine production were evaluated in a panel of human biliary tract cancer (BTC) cell lines. Human peripheral blood mononuclear cells were cultured with BTC supernatants, with and without cytokine neutralising antibodies, and analysed by flow cytometry or immunoblot.
[British Journal of Cancer]
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Auranofin Mitigates Systemic Iron Overload and Induces Ferroptosis via Distinct Mechanisms

Scientists identified iron modulators by functionally screening hepcidin agonists using a library of 640 FDA-approved drugs in human hepatic Huh7 cells.
[Signal Transduction and Targeted Therapy]
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Placental Hypoxia-Induced Alterations in Vascular Function, Morphology, and Endothelial Barrier Integrity

Placental villous explants of noncomplicated placentae and BeWo cells were subjected to hypoxia. The effect of placental hypoxic-conditioned medium on intraluminal-induced contraction and endothelial barrier integrity in chorionic arteries was investigated using pressure myography.
[Hypertension Research]
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Alteration of Immunophenotype of Human Macrophages and Monocytes after Exposure to Cigarette Smoke

Using human monocyte-derived macrophages (MDMs) from healthy donors, researchers found that cigarette smoke exposure was not associated with significant changes in the production of pro inflammatory cytokines by MDMs.
[Scientific Reports]
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Extracellular ATP Promotes Breast Cancer Invasion and Chemoresistance via SOX9 Signaling

Researchers showed that sex-determining region Y-box 9 (SOX9) was up-regulated after adenosine 5′-triphosphate treatment in breast cancer cells. In vitro invasion and migration assays demonstrated that knocking down SOX9 attenuated ATP-driven invasive capability.
[Oncogene]
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Extracellular Cold-Inducible RNA-Binding Protein Regulates Neutrophil Extracellular Trap Formation and Tissue Damage in Acute Pancreatitis

Scientists studied the role of extracellular cold-inducible RNA-binding protein, a novel damage-associated-molecular-pattern molecule, in severe acute pancreatitis.
[Laboratory Investigation]
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A Variant in IL6ST with a Selective IL-11 Signaling Defect in Human and Mouse

Researchers characterized the impact of a variant on cytokine signaling in vitro using transfected cell lines as well as primary patient-derived cells and supported these findings using a mouse model with the corresponding genome-edited variant Il6st p.R279Q.
[Bone Research]
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