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IL-6

Exposure to Cadmium Induces Neuroinflammation and Impairs Ciliogenesis in hESC-Derived 3D Cerebral Organoids

[Science of the Total Environment] The authors identified that cadmium exposure specifically induced apoptosis in neurons and inhibited the proliferation of neural progenitor cells, but neural differentiation was not significantly affected in cerebral organoids.

Effect of Adipose Derived Mesenchymal Stem Cells on Multiple Organ Injuries in Diet-Induced Obese Mice

[Tissue Barriers] Scientists studied the effect of adipose-derived MSCs on obesity-induced multi-organ injuries in a diet-induced obese mouse model.

3-Hydroxy-L-Kynurenamine Is an Immunomodulatory Biogenic Amine

[Nature Communications] Scientists reported that 3-hydroxy-L-kynurenamine was a biogenic amine produced via an alternative pathway of tryptophan metabolism.

Adversity in Early Life and Pregnancy Are Immunologically Distinct from Total Life Adversity: Macrophage-Associated Phenotypes in Women Exposed to Interpersonal Violence

[Translational Psychiatry] Researchers examined whether retrospective reports of adversity during childhood or pregnancy were associated with inflammatory imbalance, in an ethnically diverse cohort of 53 low-income women seeking family-based trauma treatment following exposure to interpersonal violence.

Kupffer Cell Restoration after Partial Hepatectomy Is Mainly Driven by Local Cell Proliferation in IL-6-Dependent Autocrine and Paracrine Manners

[Cellular & Molecular Immunology] Researchers addressed the question of whether liver macrophage restoration resulted from circulating monocyte infiltration or local kupffer cell proliferation in regenerating livers after partial hepatectomy (PHx) and uncovered the underlying mechanisms.

Elevated S-Adenosylhomocysteine Induces Adipocyte Dysfunction to Promote Alcohol-Associated Liver Steatosis

[Scientific Reports] Researchers hypothesized that increased intracellular S-adenosylhomocysteine alone caused additional related pathological changes in adipose tissue as seen with alcohol administration.

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