The authors identified that cadmium exposure specifically induced apoptosis in neurons and inhibited the proliferation of neural progenitor cells, but neural differentiation was not significantly affected in cerebral organoids.
[Science of the Total Environment]
6445212 BZCM4Q59 items 1 apa 0 default asc 1 165174 https://www.stemcellsciencenews.com/wp-content/plugins/zotpress/
%7B%22status%22%3A%22success%22%2C%22updateneeded%22%3Afalse%2C%22instance%22%3A%22zotpress-641bb6e37e7ce4233f81e823edffaf45%22%2C%22meta%22%3A%7B%22request_last%22%3A0%2C%22request_next%22%3A0%2C%22used_cache%22%3Atrue%7D%2C%22data%22%3A%5B%7B%22key%22%3A%22BZCM4Q59%22%2C%22library%22%3A%7B%22id%22%3A6445212%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Huang%20et%20al.%22%2C%22parsedDate%22%3A%222021-11-25%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%3Cdiv%20class%3D%5C%22csl-bib-body%5C%22%20style%3D%5C%22line-height%3A%202%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%5C%22%3E%5Cn%20%20%3Cdiv%20class%3D%5C%22csl-entry%5C%22%3EHuang%2C%20Y.%2C%20Dai%2C%20Y.%2C%20Li%2C%20M.%2C%20Guo%2C%20L.%2C%20Cao%2C%20C.%2C%20Huang%2C%20Y.%2C%20Ma%2C%20R.%2C%20Qiu%2C%20S.%2C%20Su%2C%20X.%2C%20Zhong%2C%20K.%2C%20Huang%2C%20Y.%2C%20Gao%2C%20H.%2C%20%26amp%3B%20Bu%2C%20Q.%20%282021%29.%20Exposure%20to%20cadmium%20induces%20neuroinflammation%20and%20impairs%20ciliogenesis%20in%20hESC-derived%203D%20cerebral%20organoids.%20%3Ci%3EScience%20of%20The%20Total%20Environment%3C%5C%2Fi%3E%2C%20%3Ci%3E797%3C%5C%2Fi%3E%2C%20149043.%20%3Ca%20href%3D%27https%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1016%5C%2Fj.scitotenv.2021.149043%27%3Ehttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1016%5C%2Fj.scitotenv.2021.149043%3C%5C%2Fa%3E%20%3Ca%20title%3D%27Cite%20in%20RIS%20Format%27%20class%3D%27zp-CiteRIS%27%20href%3D%27https%3A%5C%2F%5C%2Fwww.stemcellsciencenews.com%5C%2Fwp-content%5C%2Fplugins%5C%2Fzotpress%5C%2Flib%5C%2Frequest%5C%2Frequest.cite.php%3Fapi_user_id%3D6445212%26amp%3Bitem_key%3DBZCM4Q59%27%3ECite%3C%5C%2Fa%3E%20%3C%5C%2Fdiv%3E%5Cn%3C%5C%2Fdiv%3E%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Exposure%20to%20cadmium%20induces%20neuroinflammation%20and%20impairs%20ciliogenesis%20in%20hESC-derived%203D%20cerebral%20organoids%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Yan%22%2C%22lastName%22%3A%22Huang%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Yanping%22%2C%22lastName%22%3A%22Dai%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Min%22%2C%22lastName%22%3A%22Li%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Lulu%22%2C%22lastName%22%3A%22Guo%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Chulin%22%2C%22lastName%22%3A%22Cao%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Yuting%22%2C%22lastName%22%3A%22Huang%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Rui%22%2C%22lastName%22%3A%22Ma%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Shengyue%22%2C%22lastName%22%3A%22Qiu%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Xiaoyi%22%2C%22lastName%22%3A%22Su%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Kai%22%2C%22lastName%22%3A%22Zhong%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Yina%22%2C%22lastName%22%3A%22Huang%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Hong%22%2C%22lastName%22%3A%22Gao%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Qian%22%2C%22lastName%22%3A%22Bu%22%7D%5D%2C%22abstractNote%22%3A%22Cadmium%20%28Cd%29%20is%20an%20environmental%20heavy%20metal%20toxicant%20with%20central%20nervous%20system%20toxicity%20and%20has%20a%20greater%20negative%20impact%20on%20fetal%20neurodevelopment.%20However%2C%20the%20causative%20mechanisms%20for%20the%20neurodevelopmental%20toxicity%20of%20Cd%20have%20remained%20unclear.%20The%20human%20cerebral%20organoids%20can%20better%20mimic%20the%20three-dimensional%20structure%20of%20the%20early%20fetal%20nerve%20tissue%2C%20which%20can%20be%20used%20to%20study%20the%20developmental%20neurotoxicity%20under%20the%20condition%20of%20maternal%20exposure%20to%20Cd.%20Our%20study%20identified%20that%20Cd%20exposure%20specifically%20induced%20apoptosis%20in%20neurons%20and%20inhibited%20the%20proliferation%20of%20neural%20progenitor%20cells%2C%20but%20neural%20differentiation%20was%20not%20significantly%20affected%20in%20cerebral%20organoids.%20Cd%20exposure%20also%20elicited%20overexpression%20of%20GFAP%2C%20a%20marker%20of%20astrocytes%20and%20resulted%20in%20IL-6%20release.%20This%20study%20revealed%20that%20mineral%20absorption%20was%20significantly%20disturbed%20with%20metallothioneins%20expression%20up-regulation.%20Moreover%2C%20we%20found%20Cd%20exposure%20inhibited%20cilium-related%20gene%20expression%20and%20reduced%20ciliary%20length%20with%20increasing%20dose.%20In%20conclusion%2C%20our%20study%20has%20shown%20that%20Cd%20exposure%20regulated%20neural%20cell%20proliferation%20and%20death%2C%20induced%20neuroinflammation%2C%20enhanced%20metal%20ion%20absorption%2C%20and%20impaired%20ciliogenesis%2C%20which%20hinder%20the%20normal%20development%20of%20the%20fetal%20brain.%22%2C%22date%22%3A%22November%2025%2C%202021%22%2C%22language%22%3A%22en%22%2C%22DOI%22%3A%2210.1016%5C%2Fj.scitotenv.2021.149043%22%2C%22ISSN%22%3A%220048-9697%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Fwww.sciencedirect.com%5C%2Fscience%5C%2Farticle%5C%2Fpii%5C%2FS0048969721041152%22%2C%22collections%22%3A%5B%5D%2C%22dateModified%22%3A%222021-07-29T22%3A22%3A57Z%22%7D%7D%5D%7D
Huang, Y., Dai, Y., Li, M., Guo, L., Cao, C., Huang, Y., Ma, R., Qiu, S., Su, X., Zhong, K., Huang, Y., Gao, H., & Bu, Q. (2021). Exposure to cadmium induces neuroinflammation and impairs ciliogenesis in hESC-derived 3D cerebral organoids. Science of The Total Environment, 797, 149043. https://doi.org/10.1016/j.scitotenv.2021.149043 Cite