MTOR

[Cell Death & Disease] In silico analysis showed that epithelial membrane protein 3 (EMP3) was associated with favorable survival, and negatively regulated cell cycle S-phase. Loss and gain of function studies demonstrated that EMP3 inhibited breast cancer cell S-phage entry, DNA replication, DNA damage repair, and stem-like properties.

[Scientific Reports] Researchers presented a transgenic, TDP-43-A315T, mouse model expressing an amyotrophic lateral sclerosis phenotype and demonstrate the presence of ubiquitinated cytoplasmic TDP-43 aggregates with > 80% cell death by 28 days post differentiation in vitro.

[Nature Communications] Comparison of Tripartite motif containing protein 24 (TRIM24) in mouse mammary epithelia (Trim24COE) metaplastic carcinosarcoma morphology, TRIM24 protein levels and a derived Trim24COE gene signature revealed strong correlation with human metaplastic breast cancers (MpBC) tumors and MpBC patient-derived xenograft models.

[Cell Reports] Researchers perturbed the hepatic transcriptome through nutrient regulators to identify enduring properties of pathway organization. Diurnal regulation of energy metabolism alleviated inflammatory and proliferative stresses under physiological and pathological conditions.

[Cell Reports] Monocytes from stressed mice and humans exhibit a characteristic inflammatory transcriptomic signature and are hyperresponsive upon stimulation with Toll-like receptor ligands.

[Pharmaceutical Biology] Human hepatic carcinoma cell lines were treated with different concentrations of myristicin for 24, 48 and 72 hours. Then tetrazolium assay, flow cytometer analysis and transwell assay were performed to determine cell proliferation, apoptosis and migration/invasion, respectively.