Mammary-Specific Expression of Trim24 Establishes a Mouse Model of Human Metaplastic Breast Cancer

Comparison of Tripartite motif containing protein 24 (TRIM24) in mouse mammary epithelia (Trim24COE) metaplastic carcinosarcoma morphology, TRIM24 protein levels and a derived Trim24COE gene signature revealed strong correlation with human metaplastic breast cancers (MpBC) tumors and MpBC patient-derived xenograft models.