MTOR

[Chemico-Biological interactions] Researchers found that benzene exposure significantly increased Evi1 level in white blood cells in occupational benzene workers as well as mouse bone marrow cells.

[Science] Investigators generated a human model for tuberous sclerosis complex (TSC) by growing cerebral organoids from patients who carried mutations in TSC2.

[Molecular Cancer therapeutics] Scientists investigated the response of PTEN wild-type prostate cancer cell lines to the dual PI3K/mTOR inhibitor DS-7423 alone or in combination with HER2 inhibitors or mGluR1 inhibitors.

[Hepatology] The therapeutic efficacy and the molecular pathways targeted by TVB3664, either alone or with tyrosine kinase inhibitors or the checkpoint inhibitor anti-PD-L1 antibody, were assessed in human HCC cell lines and multiple oncogene-driven HCC mouse models.

[Science Advances] Scientists showed in hepatocellular carcinoma (HCC) cells, xenografts, and patient-derived organoids that fasting improved sorafenib efficacy and acted synergistically to sensitize sorafenib-resistant HCC.

[Scientific Reports] To find additional hematologic entities with ectopic expression of BCL2 family members, investigators performed expression screening of cell lines applying the LL-100 panel.