MYCN

[Oncogene] Effects of drug combinations on cell viability, proliferation, apoptosis and colony forming were assessed in a panel of neuroblastoma cell lines.

[Cancer Research] Researchers showed that the growth arrest-specific 7 (GAS7) gene, located at chromosome band 17p13.1, is preferentially deleted in high-risk MYCN-driven neuroblastoma.

[Proceedings of the National Academy of Sciences of the United States of America] Investigators provided an insight into the developing adrenal gland and introduced the Schwann cell precursor gene signature as being of interest for further research in understanding neuroblastoma phenotype.

[EMBO Journal] Scientists tested whether anaplastic lymphoma kinase AL2 (ALKAL2) ligand could potentiate neuroblastoma progression in the absence of ALK mutation

[Communications Biology] The authors showed that an androgen-deprivation therapy-stimulated transcription factor, ZBTB46, upregulated NGF via ZBTB46 mediated-transcriptional activation of nerve growth factor.

[Scientific Reports] Researchers investigated the potential of 18F-mFBG, a positron emission tomography analogue of the 123I-mIBG radiotracer, to quantify norepinephrine transporter expression levels in mouse models of neuroblastoma following treatment with AZD2014, a dual mTOR inhibitor.