NSCLC

[Cell Death & Disease] Scientists demonstrated that transmembrane protein (TMEM) 116 was highly expressed in NSCLC tissues and cell lines.

[Cell Death Discovery] Researchers showed that gefitinib significantly induced downregulation of Sterol Regulator Element Binding (SREBP1) in therapy-sensitive cells.

[Cell Death & Disease] Scientists performed the first drug repurposing screen to identify compounds that confer synthetic lethality with LIM domains containing 1 (LIMD1) loss in NSCLC cells.

[Biochemical and Biophysical Research Communications] NSCLC cell lines with acquired radioresistance to X-rays were obtained through fractionated irradiation. The differentially expressed proteins between the self-established radioresistant NSCLC cell line A549-R11 and control were measured by proteomic analysis.

[Cell Death & Disease] The authors detected a higher concentration of CD73+ tumor-derived extracellular vesicles enriched in exosomes in central and peripheral body fluids of glioblastoma patients than in those of patients with other brain tumors.

[Cell Death & Disease] Scientists showed that ubiquitin specific peptidase 5 (USP5) was a novel PD-L1 deubiquitinase in non-small cell lung cancer (NSCLC) cells. USP5 directly interacted with PD-L1 and deubiquitinated PD-L1, therefore enhances PD-L1 protein stability.