NSCLC

[International Journal of Cancer] Reserachers investigated associations between 31,032 single nucleotide polymorphisms (SNPs) in 368 mitotic phase-related pathway genes and overall survival (OS) of patients with non-small cell lung cancer (NSCLC).

[Annals of Medicine] Researchers intended to investigate role and mechanism of circ_0010235 in non-small-cell lung cancer proliferation, migration and invasion.

[Thoracic Cancer] To verify the relationship between SGMS1-AS1, miR-106a-5p, and MYLIP, scientists overexpressed miR-106a-5p inhibitor or MYLIP in lung adenocarcinoma cells after decreasing SGMS1-AS1 and repeated the above assays.

[International Journal of Molecular Sciences] Scientists review the biological role of protein kinase C (PKC) isozymes in non-small cell lung cancer through extensive analysis of cell-line-based studies to better understand the rationale for PKC inhibition.

[Onconova Therapeutics, Inc. (Globe Newswire, Inc.)] Onconova Therapeutics, Inc. announced that the first patient has been dosed in the US Phase I clinical trial of ON 123300, the company’s novel multi-kinase inhibitor, for HR+ HER 2- metastatic breast cancer patients who are refractory to, or progressing on, currently approved CDK 4/6 inhibitors.

[Bristol Myers Squibb, Inc. (Business Wire, Inc.)] Bristol Myers Squibb, Inc. announced that Opdivo (nivolumab) plus Yervoy (ipilimumab) with two cycles of chemotherapy showed a durable survival benefit compared to four cycles of chemotherapy alone after two years of follow-up in previously untreated patients with advanced non-small cell lung cancer (NSCLC).