Cancer Stem Cell News
Cell Therapy News
Dermal Cell News
Endothelial Cell News
ESC & iPSC News
Extracellular Matrix News
Hematopoiesis News
Hepatic Cell News
Human Immunology News
Immune Regulation News
Intestinal Cell News
Mammary Cell News
Mesenchymal Cell News
Muscle Cell News
Neural Cell News
Organoid News
Pancreatic Cell News
Prostate Cell News
Pulmonary Cell NewsTo verify the relationship between SGMS1-AS1, miR-106a-5p, and MYLIP, scientists overexpressed miR-106a-5p inhibitor or MYLIP in lung adenocarcinoma cells after decreasing SGMS1-AS1 and repeated the above assays.
[Thoracic Cancer]
7753456 UR7GGSGW items 1 apa 0 default asc 1 162974 https://www.stemcellsciencenews.com/wp-content/plugins/zotpress/
%7B%22status%22%3A%22success%22%2C%22updateneeded%22%3Afalse%2C%22instance%22%3A%22zotpress-6a6fd48e5995e493019db5bc195f8558%22%2C%22meta%22%3A%7B%22request_last%22%3A0%2C%22request_next%22%3A0%2C%22used_cache%22%3Atrue%7D%2C%22data%22%3A%5B%7B%22key%22%3A%22UR7GGSGW%22%2C%22library%22%3A%7B%22id%22%3A7753456%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Liu%20et%20al.%22%2C%22numChildren%22%3A0%7D%2C%22bib%22%3A%22%3Cdiv%20class%3D%5C%22csl-bib-body%5C%22%20style%3D%5C%22line-height%3A%202%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%5C%22%3E%5Cn%20%20%3Cdiv%20class%3D%5C%22csl-entry%5C%22%3ELiu%2C%20T.%2C%20Yang%2C%20C.%2C%20Wang%2C%20W.%2C%20%26amp%3B%20Liu%2C%20C.%20%28n.d.%29.%20LncRNA%20SGMS1-AS1%20regulates%20lung%20adenocarcinoma%20cell%20proliferation%2C%20migration%2C%20invasion%2C%20and%20EMT%20progression%20via%20miR-106a-5p%5C%2FMYLI9%20axis.%20%3Ci%3EThoracic%20Cancer%3C%5C%2Fi%3E%2C%20%3Ci%3En%5C%2Fa%3C%5C%2Fi%3E%28n%5C%2Fa%29.%20%3Ca%20href%3D%27https%3A%5C%2F%5C%2Fdoi.org%5C%2Fhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1111%5C%2F1759-7714.14043%27%3Ehttps%3A%5C%2F%5C%2Fdoi.org%5C%2Fhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1111%5C%2F1759-7714.14043%3C%5C%2Fa%3E%20%3Ca%20title%3D%27Cite%20in%20RIS%20Format%27%20class%3D%27zp-CiteRIS%27%20href%3D%27https%3A%5C%2F%5C%2Fwww.stemcellsciencenews.com%5C%2Fwp-content%5C%2Fplugins%5C%2Fzotpress%5C%2Flib%5C%2Frequest%5C%2Frequest.cite.php%3Fapi_user_id%3D7753456%26amp%3Bitem_key%3DUR7GGSGW%27%3ECite%3C%5C%2Fa%3E%20%3C%5C%2Fdiv%3E%5Cn%3C%5C%2Fdiv%3E%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22LncRNA%20SGMS1-AS1%20regulates%20lung%20adenocarcinoma%20cell%20proliferation%2C%20migration%2C%20invasion%2C%20and%20EMT%20progression%20via%20miR-106a-5p%5C%2FMYLI9%20axis%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Ting%22%2C%22lastName%22%3A%22Liu%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Chunli%22%2C%22lastName%22%3A%22Yang%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Weizhen%22%2C%22lastName%22%3A%22Wang%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Chunmei%22%2C%22lastName%22%3A%22Liu%22%7D%5D%2C%22abstractNote%22%3A%22Background%20Lung%20cancer%20mainly%20includes%20non-small%20cell%20lung%20cancer%20%28NSCLC%29.%20Lung%20adenocarcinoma%20%28LUAD%29%20is%20the%20main%20subtype%20of%20NSCLC.%20Long%20non-coding%20RNAs%20%28LncRNAs%29%20had%20been%20found%20to%20exert%20numerous%20functions%20on%20the%20progressions%20of%20cancers.%20MicroRNAs%20often%20exist%20as%20the%20target%20of%20LncRNAs%20to%20regulate%20a%20series%20of%20signaling%20pathways%20in%20human.%20We%20explored%20the%20effects%20and%20molecular%20mechanism%20of%20LncRNA%20SGMS1-AS1%20on%20the%20procedures%20of%20LUAD%20cells.%20Methods%20The%20ENCORI%20and%20GEPIA%20databases%20were%20used%20to%20analyze%20the%20differences%20in%20SGMS1%2C%20miR-106a-5p%2C%20and%20MYLIP%20between%20LUAD%20and%20normal%20tissue.%20Their%20expression%20levels%20were%20examined%20by%20RT-PCR.%20CCK8%2C%20colony%20formation%2C%20migration%2C%20and%20invasion%20assay%20were%20conducted%20in%20LUAD%20cells%20which%20had%20silenced%20SGMS1-AS1.%20To%20verify%20the%20relationship%20between%20SGMS1-AS1%2C%20miR-106a-5p%2C%20and%20MYLIP%2C%20we%20overexpressed%20miR-106a-5p%20inhibitor%20or%20MYLIP%20in%20LUAD%20cells%20after%20decreasing%20SGMS1-AS1%20and%20repeated%20the%20above%20assays.%20Results%20SGMS1-AS1%20was%20downregulated%20in%20LUAD%20tissue%20as%20well%20as%20cells%2C%20which%20was%20related%20to%20good%20prognosis%20of%20patients%20with%20lung%20adenocarcinoma.%20Additionally%2C%20knockdown%20of%20SGMS1-AS1%20promoted%20proliferation%2C%20migration%2C%20invasion%2C%20and%20epithelial%20mesenchymal%20transition%20%28EMT%29%20progression%20of%20LUAD%20cells%2C%20which%20meant%20that%20SGMS1-AS1%20inhibited%20the%20progression%20of%20LUAD%20cells.%20Furthermore%2C%20miR-106a-5p%20was%20the%20direct%20target%20of%20SGMS1-AS1%20and%20transfecting%20miR-106a-5p%20inhibitor%20could%20reversed%20the%20impact%20induced%20by%20knockdown%20of%20SGMS1-AS1.%20Subsequently%2C%20we%20found%20that%20MYLIP%20was%20the%20target%20of%20miR-106a-5p%2C%20which%20was%20negatively%20correlated%20with%20miR-106a-5p%2C%20but%20had%20high%20positive%20correlation%20with%20SGMS1-AS1.%20Consistently%2C%20overexpression%20MYLIP%20partly%20eliminated%20the%20effects%20on%20A549%20cells%20induced%20by%20silencing%20of%20SGMS1-AS1.%20Conclusion%20LncRNA%20SGMS1-AS1%20inhibits%20the%20proliferation%2C%20invasion%2C%20migration%20and%20EMT%20progression%20of%20LUAD%20cells%20via%20targeting%20miR-106a-5p%5C%2FMYLIP%20axis.%22%2C%22date%22%3A%22%22%2C%22language%22%3A%22en%22%2C%22DOI%22%3A%22https%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1111%5C%2F1759-7714.14043%22%2C%22ISSN%22%3A%221759-7714%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Fonlinelibrary.wiley.com%5C%2Fdoi%5C%2Fabs%5C%2F10.1111%5C%2F1759-7714.14043%22%2C%22deleted%22%3A1%2C%22collections%22%3A%5B%2243ZBJFKZ%22%5D%2C%22dateModified%22%3A%222021-06-03T18%3A10%3A56Z%22%7D%7D%5D%7D
Liu, T., Yang, C., Wang, W., & Liu, C. (n.d.). LncRNA SGMS1-AS1 regulates lung adenocarcinoma cell proliferation, migration, invasion, and EMT progression via miR-106a-5p/MYLI9 axis. Thoracic Cancer, n/a(n/a). https://doi.org/https://doi.org/10.1111/1759-7714.14043 Cite
