NSCLC

[Genome Medicine] The authors combined new and previously published single-cell RNA-seq data from 98,015 single cells from a total of 66 gliomas to profile 19,331 individual macrophages.

[Molecular Therapy-Oncolytics] Scientists discuss the technologies for detection and enrichment of circulating tumor cells, as well as clinical applications involving circulating tumor cells.

[Merus, Inc. (Business Wire, Inc.)] Merus N.V. (Nasdaq: MRUS), announced new collaborations in Israel, Italy and Spain to expand molecular screening opportunities for patients with cancers that may have neuregulin 1 fusions and to raise awareness of the Merus eNRGy clinical trial of its bispecific antibody zenocutuzumab.

[Nature Communications] Researchers showed that MEK inhibition enhanced PD-L1 expression while PD-L1 blockade upregulated MAPK signaling in mutant KRAS lung tumors.

[Respiratory Research] Researchers elucidated the expression and role of long non-coding RNA (lncRNA)-PCAT-1, a potential biomarker for drug resistance and a therapeutic target for non-small-cell lung cancer (NSCLC), in gefitinib resistance in NSCLC cells.

[Science Translational Medicine] In vitro non-small lung cancer and mammary adenocarcinoma models showed that auranofin-induced inhibition of glutathione- and thioredoxin-dependent hydrogen peroxide metabolism selectively enhanced Avasopasem manganese-induced killing of cancer cells compared to normal cells.