Avasopasem Manganese Synergizes with Hypofractionated Radiation to Ablate Tumors through the Generation of Hydrogen Peroxide

In vitro non-small lung cancer and mammary adenocarcinoma models showed that auranofin-induced inhibition of glutathione- and thioredoxin-dependent hydrogen peroxide metabolism selectively enhanced Avasopasem manganese-induced killing of cancer cells compared to normal cells.