Nanog

[Oncogene] Investigators demonstrated that ZEB2, the transcription factor of epithelial–mesenchymal transition, was upregulated in ascites cells from high-grade serous ovarian cancer patients and in CD133+ cancer stem-like cells from epithelial ovarian cancer cell lines.

[Stem Cell Reports] Researchers developed a rapid protein-level OCT4 depletion system that demonstrated that the immediate downstream response to loss of OCT4 was reduced expression of key pluripotency factors.

[Heliyon] The authors determined differences in ultrastructural morphology, proliferative capacity, and mouse-xenotransplantation characteristics of the MDA-MB-231 and MDA-MB-436 triple-negative breast tumor cell lines with the CD44high/CD24low phenotype in order to study their exosomes.

[Stem Cell Research & Therapy] Researchers generated iPSCs from 3 different GS-2 patients using lentiviral vectors. The iPSCs were characterized using flow cytometry and RT-PCR and tested for the expression of pluripotency markers. In vivo differentiation to cells from all three germlines was tested using a teratoma assay. In vitro differentiation of GS-2 iPSCs into hematopoietic stem and progenitor cells was done using Op9 feeder layers and specified media.

[Cell and Bioscience] Scientists investigated the effect of direct contact of prostate cancer (PCa) cells with mesenchymal stem cells on the stemness of PCa and its mechanisms.

[Cancer Research] Interleukin enhancer binding factor 2 (ILF2) facilitated nuclear mRNA export and inhibited hMTR4-mediated exosomal degradation to promote stabilization and expression of SOX2, NANOG, and SALL4, resulting in enhanced stemness and tumor-initiating capacity of esophageal cancer cells.