Oct4

[Oncogene] Investigators demonstrated that ZEB2, the transcription factor of epithelial–mesenchymal transition, was upregulated in ascites cells from high-grade serous ovarian cancer patients and in CD133+ cancer stem-like cells from epithelial ovarian cancer cell lines.

[Stem Cell Reports] Researchers developed a rapid protein-level OCT4 depletion system that demonstrated that the immediate downstream response to loss of OCT4 was reduced expression of key pluripotency factors.

[Nature Communications] Researchers showed the essential role of disease phase-specific transcription factor collaboration changes in advanced prostate cancer.

[Experimental & Molecular Medicine] Investigators discuss the roles of the structural components of Oct proteins in reprogramming and how donor cell epigenomes endow Oct proteins with different reprogramming competences.

[Heliyon] The authors determined differences in ultrastructural morphology, proliferative capacity, and mouse-xenotransplantation characteristics of the MDA-MB-231 and MDA-MB-436 triple-negative breast tumor cell lines with the CD44high/CD24low phenotype in order to study their exosomes.

[Proceedings of the National Academy of Sciences of the United States of America] Scientists examined epigenome remodeling at the onset of human nuclear reprogramming by profiling human fibroblasts after fusion with murine ESCs. Efficient reprogramming of human fibroblasts to iPSCs was achieved by transduction with vectors expressing SOX2, KLF4, and inducible dnAP-1, demonstrating that dnAP-1 can substitute for exogenous human OCT4.