Oct4

[Aging] Researchers underscored the effect of maternal age on the biological characteristics and stemness properties of placenta-derived mesenchymal stem cells.

[Inflammation Research] miR-342-3p overexpression in LCSC lead to lower tumor volume, reduced tumor spheroid formation and agar colony formation rates, as well as lower mRNA and protein expressions of CD44, ALDH1, Bmi1, Sox2, and Oct4.

[Aging] Researchers investigated the effect of maternal age on the biological characteristics and stemness properties of placenta-derived MSCs (PDMSCs). PDMSCs were isolated from 5 donor age groups for comparison of morphological, proliferative and differentiation properties.

[Molecular Therapy-Methods & Clinical Development] Using Measles reprogramming vectors, researchers presented microRNA-targeting of exogenous OCT4 to shut down its expression during the mesenchymal to the epithelial transition phase of reprogramming.

[Biochemical Society Transactions] Scientists review the state-of-the-art knowledge of compartmentalization in the cell nucleus and the relevance of this process for transcriptional regulation, particularly in PSCs.

[American Journal of Hematology] The authors developed a murine model to investigate the in vivo properties of human iPSC-red blood cells (RBCs). iPSC lines were produced from human peripheral blood mononuclear cells by transient expression of plasmids containing OCT4, SOX2, MYC, KLF4 and BCL-XL genes.