Oct4

[Cell Death Discovery] The authors found that the stemness characteristics of lung cancer cells were significantly enhanced by the overexpression of non-muscle myosin heavy chain 9 (MYH9), and the knockout of MYH9 had the opposite effects.

[Life Science Alliance] The authors used Resf1 knockout cell lines to determine the requirements of RESF1 for ESC self-renewal and for in vitro specification of ESCs into primordial germ cell-like cells

[Cellular Oncology] Cell line-derived spheroids, ex vivo intestinal organoid cultures and induced-pluripotent stem cells were used to investigate the role of atypical cyclin P in stemness.

[Reproductive Toxicology] To explore the developmental toxicity of 2,2',4,4'-Tetrabromodiphenyl ether (BDE47), mouse ESCs, which are ideal models for testing the developmental toxicity of environmental contaminants in vitro, were exposed to BDE47 for 24 h or 48 h in this study.

[Cell Biology International] CD133+ cells were sorted from prostate cancer cells using magnetic fluorescence cell sorting technology and were considered as cancer stem cells.

[Development] Researchers reported that the conjunct activity of two orphan nuclear receptors, Esrrb and Nr5a2, paralleled the importance of that of Oct4 and Sox2 in naïve mouse ESCs. By occupying a large common set of regulatory elements, these two factors controlled the binding of Oct4, Sox2 and Nanog to DNA.