Programmed death ligand 1 (PD-L1) expression in human ovarian cancer cells after PARP inhibitors treatment was examined by western blotting and flow cytometry.
[Journal of Translational Medicine]
[zotpress userid=” items=’AAAAAAAA’ style=’apa’ cite=’yes’]
Investigators demonstrated the relevance of genetic germline diagnostics in elucidating the causes of myeloproliferative neoplasms (MPNs) and suggested novel therapeutic options in MPNs.
[zotpress userid=’7992332′ items=’AAAAAAAA’ style=’apa’ cite=’yes’]
In cell lines, BRCA1 loss was associated with stabilized cyclin E1 during the cell cycle, and BRCA1 siRNA led to increased cyclin E1 in association with reduced phospho-cyclin E1 T62.
[npj Breast Cancer]
[zotpress userid=’7992332′ items=’LVJ2LSCB’ style=’apa’ cite=’yes’]
Genetic deletion or methylation of DNA-sensing/IFN genes or CCL5 chemokine was identified as a potential mechanism to attenuate T cell inflammation.
[zotpress userid=” items=’LE78Y4RB’ style=’apa’ cite=’yes’]
Scientists summarize the diverse processes underlying resistance to poly(ADP-ribose) polymerase (PARP) inhibitors and discuss the potential strategies that might overcome these mechanisms such as combinations with chemotherapies, targeting the acquired vulnerabilities associated with resistance to PARP inhibitors or suppressing genomic instability.
[Nature Reviews Clinical Oncology]
[zotpress userid=’7992332′ items=’ENVKZMG6′ style=’apa’ cite=’yes’]
Using a combination of in vivo and in vitro analyses in a novel PyMT-E2A conditional knockout mouse model and derived primary tumor cell lines, researchers reported an essential role of E2A in stemness, metastasis, and therapeutic resistance in breast cancer.
[zotpress userid=” items=’6XJ2RWYD’ style=’apa’ cite=’yes’]
Investigators provided evidence that the CSC-related transcription factor Oct4 contributes to head and neck squamous cell carcinoma radioresistance by regulating DNA damage response and the CSC phenotype.
[zotpress userid=” items=’WVNMWLMG’ style=’apa’ cite=’yes’]
Scientists review the current understanding of the molecular mechanisms underlying DNA damage-triggered immune responses, including cytosolic DNA sensing via the cGAS/STING pathway.
[Genes & Development]
[zotpress userid=’6445218′ items=’5XKFFALH’ style=’apa’ cite=’yes’]
Ongoing research to establish predictive biomarkers for the treatment of tumors with resistance to second-generation androgen receptor antagonists led to the approval of the PARP inhibitors olaparib and rucaparib in pre-treated metastatic castration-resistant prostate cancer.
[Nature Reviews Urology]
[zotpress userid=’6807162′ items=’GBJDIUM7′ style=’apa’ cite=’yes’]
The combination of MS023, a type I protein arginine methyltransferases (PRMT) inhibitor, and the PARP inhibitor BMN-673 demonstrated strong synergistic interaction at low nanomolar concentrations in methylthioadenosine phosphorylase-negative NSCLC cell lines A549, SK-LU-1 and HCC4006.
[zotpress userid=’6606345′ items=’CEQLNDLR’ style=’apa’ cite=’yes’]
The authors investigated the possibility to predict BRCA1 promoter methylation status based on the morphological and immunohistochemical features of TNBCs.
[Journal of Human Genetics]
[zotpress userid=’6807162′ items=’R4NRI79W’ style=’apa’ cite=’yes’]