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PBMCs
Human Immunology News
NLRP3 Inflammasome Activation in Human Peripheral Blood Mononuclear Cells Induced by Venoms Secreted PLAM2s
[International Journal of Biological Macromolecules] Peripheral blood mononuclear cells were isolated by density gradient and incubated with RPMI, LPS, BthTX-I or BthTX-II isolated from Bothrops jararacussu venom, to evaluate viability, and the results showed that there was no cell death.
Human Immunology News
Reinvestigation of Classic T Cell Subsets and Identification of Novel Cell Subpopulations by Single-Cell RNA Sequencing
[Journal of Immunology] The authors integrated six bead-enriched T cell subsets with 62,235 single-cell transcriptomes from human PBMCs and clustered them into nine scRNA-seq clustered populations.
Human Immunology News
Key Interactions in the Trimolecular Complex Consisting of the Rheumatoid Arthritis-Associated DRB1*04:01 Molecule, the Major Glycosylated Collagen II Peptide and the T Cell Receptor
[Annals of the Rheumatic Diseases] The crystal structures identified peptide binding to DRB1*04:01 and potential side chain exposure to T cells.
Human Immunology News
Adenosine Receptor A2a Blockade by Caffeine Increases IFN–Gamma Production in Th1 Cells from Patients with Rheumatoid Arthritis
[Scandinavian Journal of Rheumatology] Peripheral blood mononuclear cells were obtained from the peripheral blood of healthy individuals and patients with rheumatoid arthritis.
Immunology of Infectious Disease News
Single-Cell Analysis Reveals the Immune Characteristics of Myeloid Cells and Memory T Cells in Recovered COVID-19 Patients with Different Severities
[Frontiers in Immunology] According to large-scale single-cell analysis, recovered patients, who had severe symptoms, still exhibited peripheral immune disorders one-two months after symptom onset.
Human Immunology News
TGFβ2 Induces the Soluble Isoform of CTLA-4 – Implications for CTLA-4 Based Checkpoint Inhibitor Antibodies in Malignant Melanoma
[Frontiers in Immunology] Scientists examined the effect of selectively blocking the function of sCTLA-4 on in vitro immune responses from volunteer healthy or melanoma patient PBMC samples.