PDGF

[Cell Death & Disease] Researchers found a potential association between deletion of smooth muscle 22α and deregulated nuclear receptors liver X receptors /retinoid X receptor signaling in mice.

[Cell Metabolism] The authors showed that skeletal muscle of type 2 diabetes mellitus patients exhibited degenerative remodeling of the ECM that was associated with a selective increase of a subpopulation of fibro-adipogenic progenitors (FAPs) marked by expression of THY1 (CD90)—the FAPCD90+.

[Leukemia] Scientists examined the effects of plasma from myeloma patients at diagnosis and in complete remission and from healthy donors on the osteoblastic differentiation of healthy donor-derived adipose-dervied MSCs.

[American Journal of Physiology-Heart and Circulatory Physiology] Scientists identified several regulatory regions that control DSTN expression including a SMC-selective enhancer that was activated by the MRTF/SRF, Notch/RBPJ, and SMAD transcription factors.

[Cell Death Discovery] The authors showed dual regulatory functions of bone marrow-derived mesenchymal stem cells in attenuating hepatic fibrosis by promoting Ly6Chi/Ly6Clo subset conversion and Ly6Clo macrophage restoration through secreting antifibrogenic-cytokines and activating the apoptotic pathway.

[Respiratory Research] Researchers explored the role of tumor necrosis factor-α-induced protein 8-like 2 (TIPE2) in the regulation of airway smooth muscle cells, which are one of the main effector cells in the development of asthma.