PI3K

[Cell Cycle] Gain- and loss- of function assay verified the impact of circ-PITX1 and miR-30e-5p on the proliferation, invasion, and migration of NSCLC cells.

[Journal of Nanobiotechnology] Researchers investigated the effects of exosomes derived from bone marrow mesenchymal stem cells on the regulation of acute myeloid leukemia and the underlying mechanisms mediated by microRNA.

[Scientific Reports] Investigators established a model of CSCs that was originally developed from mouse induced pluripotent stem cells (miPSCs) by proposing miPSCs to the conditioned medium of cancer derived cells, which was a mimic of carcinoma microenvironment.

[Aging] Breast cancer cells were transfected with N-glycosylation mutation EpCAM plasmid to express deglycosylated EpCAM. Investigators showed that deglycosylated EpCAM promoted autophagy in breast cancer cells.

[European Journal of Pharmacology] Investigators established chemo-resistant melanoma cells and found that expression of stemness genes were upregulated in the resistant melanoma cells. And Astragalus polysaccharide could downregulate expression of stemness genes.

[Proceedings of the National Academy of Sciences of the United States of America] The authors engineered the highly migratory and brain tumor tropic human neural stem cells LM008 to continuously secrete high amounts of functional, stable, full-length antibodies against human epidermal growth factor receptor 2 (HER2) without compromising the stemness of LM008 cells.