PI3K

[Scientific Reports] Scientists screened a total of 521 tumor specimens from Chinese patients with lung cancer for anaplastic lymphoma receptor tyrosine kinase fusion by immunohistochemistry and confirmed by fluorescence in situ hybridization.

[Chemistry & Biodiversity] Geranyl-2,4-dihydroxy-6-phenethylbenzoate (GDP), isolated from Boesenbergia pandurata rhizomes, exhibited potent preferential cytotoxicity against PANC-1 human pancreatic cancer cells under nutrition starvation conditions.

[Science Advances] Scientists genetically engineered MSCs with Exendin-4, a glucagon-like peptide-1 analog, and demonstrated their boosted cellular functions and antidiabetic efficacy in a type 2 diabetes mellitus mouse model.

[Acta Biomaterialia] The authors synthesized a sodium alginate (SA)/collagen type I (Col)/stromal cell-derived factor-1 (SDF-1) hydrogel and investigated whether the SA/Col/SDF-1 hydrogel loaded with bone marrow-derived MSCs had therapeutic effects on a traumatic brain injury model.

[Molecular Medicine Reports] M2‑like tumor‑associated macrophages (TAMs) accelerated the metastasis and increased the stemness of anaplastic thyroid carcinoma cells, and the underlying mechanism may have been related to the section of insulin‑like growth factor by M2‑like TAMs, which activated the IR‑A/IGF1R‑mediated PI3K/AKT/mTOR signaling pathway.

[Molecular Therapy-Nucleic Acids] Scientists screened multi-layer molecular data of 36 pancreatic cancer cell lines, including gene mutation, gene expression, miRNA expression, and protein profiles.