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PI3K

Blocking PI3K p110β Attenuates Development of PTEN-Deficient Castration-Resistant Prostate Cancer

[Molecular Cancer Research] Researchers found that combining p110β with RAC/PAK1 or tankyrase inhibitors significantly reduced the growth of murine and human CRPC organoids in vitro and in vivo.

RNA-Seq of Nine Canine Prostate Cancer Cell Lines Reveals Diverse Therapeutic Target Signatures

[Cancer Cell International] Investigators compared the transcriptomes of nine canine cell lines derived from prostate adenocarcinoma (PAC), PAC metastasis and transitional cell carcinoma to their respective original primary tumor or metastasis tissues.

CD97 Is Associated with Mitogenic Pathway Activation, Metabolic Reprogramming, and Immune Microenvironment Changes in Glioblastoma

[Scientific Reports] Using in silico and in vitro techniques, investigators demonstrated heterogeneous expression of CD97, a leukocyte adhesion marker, in human glioblastoma.

Evi1 Involved in Benzene-Induced Hematotoxicity via Modulation of PI3K/mTOR Pathway and Negative Regulation Serpinb2

[Chemico-Biological interactions] Researchers found that benzene exposure significantly increased Evi1 level in white blood cells in occupational benzene workers as well as mouse bone marrow cells.

Pregnancy-Associated Plasma Protein-a (PAPP-a) Is a Key Component of an Interactive Cellular Mechanism Promoting Pulmonary Fibrosis

[Journal of Cellular Physiology] The authors found a highly significant correlation between pregnancy-associated plasma protein (PAPP)-A expression in IPF lung tissue and disease severity as measured by various pulmonary and physical function tests.

Proteomic Profile of Extracellular Matrix from Native and Decellularized Chorionic Canine Placenta

[Journal of Proteomics] The authors studied the proteome profiled of canine native and decellularized placenta to characterize the proteome related to maintenance of a microenvironment and structure suitable for tissue engineering applications.

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