PKM2

[Scientific Reports] Using a genetically encoded sensor for NADPH/NADP+ redox state, researchers showed overexpression of FGFR5 enhanced glucose-stimulated NADPH metabolism in beta-cell lines as well as mouse and human beta-cells

[Circulation Research] Genetic deletion of pyruvate kinase muscle 2 (PKM2) in myeloid cells or limiting its nuclear translocation reduced atherosclerosis by suppressing inflammation and enhancing efferocytosis.

[Circulation Research] Genetic deletion of pyruvate kinase muscle 2 (PKM2) in myeloid cells or limiting its nuclear translocation reduced atherosclerosis by suppressing inflammation and enhancing efferocytosis.

[Hypertension] Researchers investigated pulmonary arterial smooth muscle cell aerobic glycolysis after being treated with platelet supernatant. TGF-βRI, PKM2, and other antagonists were applied to identify the underlying mechanism

[Cancer Research] Researchers explored the potential of antisense oligonucleotides (ASO)-based pyruvate kinase (PKM) splice switching as a targeted therapy for liver cancer. A more potent lead constrained-ethyl/DNA ASO induced PKM splice switching and inhibited the growth of cultured HCC cells.

[Journal of Biomedical Science] Combination treatment of docetaxel with caffeic acid phenethyl ester effectively suppressed the proliferation and survival of docetaxel-resistant prostate cancer cells via inhibition of Bcl-2 and c-Myc as well as induction of metabolism interference.