Investigators demonstrated that pyruvate kinase M2 stimulated inflammatory and apoptosis signaling pathways in pulmonary artery smooth muscle cells (PASMCs) and promoted PASMC migration and proliferation.
Zhang, A., Yu, F., Yu, W., Ye, P., Liu, P., Gu, Y., Chen, S., & Zhang, H. (2020). Pyruvate kinase M2 activation protects against the proliferation and migration of pulmonary artery smooth muscle cells. Cell and Tissue Research. https://doi.org/10.1007/s00441-020-03245-2Cite