PKM2

[iScience] The authors reported that myofibroblasts expressed and secreted PKM2. Extracellular PKM2 upregulated arginase-1 expression in myofibroblasts, therefore facilitating proline biosynthesis and subsequent collagen production.

[Journal of Experimental & Clinical Cancer Research] Investigators found that LNCAROD was significantly upregulated and predicted a poorer prognosis in hepatocellular carcinoma (HCC) patients. LNCAROD significantly promoted HCC cell proliferation, migration, invasion, and chemoresistance both in vitro and in vivo.

[Oncogene] Researchers reported that knockdown of splicing factor, proline- and glutamine-rich (SFPQ) expression in melanoma cells decelerated several cancer-associated cell phenotypes, including cell growth, migration, epithelial to mesenchymal transition, apoptosis, and glycolysis.

[Experimental Cell Research] The authors characterized the cellular expression and localization patterns of pyruvate kinase muscle isoforms in mouse ESCs, chemically transitioned epiblast-like cells (mEpiLCs) representing formative pluripotency, and mEpiSCs using immunoblotting and confocal microscopy.

[Cancer Research] Scientists identified a drug, HA344, that concomitantly targets two distinct metabolic hubs in cancer cells.

[Cell Metabolism] Scientists uncovered and characterized a distinct population of inflammatory hepatic CXCR3+Th17 (ihTh17) cells sufficient to exacerbate non-alcoholic fatty liver disease pathogenesis.