PTEN

[Biochemical Genetics] Min6 cells were induced by 5 mg/dl UA and the cell proliferation, apoptosis, and insulin release were evaluated using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay, flow cytometry and glucose-stimulated insulin secretion, respectively.

[Scientific Reports] Researchers employed lineage-tracing to demonstrate the tumorigenicity potential of the Pten-, SOX9+ cells. They showed that these cells were capable of giving rise to mixed-lineage tumors that manifested features of both hepatocellular carcinoma (HCC) and intrahepatic cholangiocarcinoma (CCA).

[Cell Death & Disease] Scientists clarified the role of KLHL38 in non-small cell lung cancer (NSCLC). KLHL38 expression was evaluated in tumor and adjacent normal tissues from 241 patients with NSCLC using immunohistochemistry and real-time PCR, and its association with clinicopathological parameters was analyzed.

[Cell Death & Differentiation] Investigators generated and analyzed knock-in mice expressing a mutant form of PTEN that could not be phosphorylated by ataxia telangiectasia mutated (ATM), which accelerated tumorigenesis in a model of HER2-positive breast cancer.

[International Journal of Molecular Sciences] Investigators studied the effect of syndecan-1 siRNA depletion and hyaluronic acid treatment on hallmark processes of cancer in breast cancer cell lines of different levels of aggressiveness.

[Cancer Research] Oral administration of an antibiotic mixture in prostate cancer (PCa)-bearing mice fed a high-fat diet containing a large proportion of lard drastically altered the composition of the gut microbiota including Rikenellaceae and Clostridiales, inhibited PCa cell proliferation, and reduced prostate Igf1 expression and circulating IGF-1 levels.