RAS

[Cancer Gene Therapy] In primary prostate luminal epithelial cells, following inducible oncogenic Kras expression or Pten depletion, TMPRSS2-ERG suppressed oncogene-induced senescence, independent of TP53 induction and RB1 inhibition.

[Anti-Cancer Drugs] Scientists investigated whether the novel factor 3,5-dihydroxy-4-methoxybenzyl alcohol, suppressed the activity of metastatic human prostate cancer PC-3 or DU-145 cells.

[Science Signaling] The authors found that glucocorticoid receptor was present in cytoplasmic KRAS-containing complexes and inhibited the activation of wild-type and oncogenic KRAS in mouse embryonic fibroblasts and human lung cancer A549 cells.

[Cell Death & Disease] GNG2 over-expression could significantly block the cell cycle, inhibit proliferation, and promote apoptosis in breast cancer cells in vitro.

[Cancer Research] The authors established cells with acquired resistance to the allosteric SHP2 inhibitor SHP099 from two FLT3-ITD-positive AML cell lines.

[Inflammation] Investigators focused on how miR-98-5p functioned in the proliferation and migration of human airway smooth muscle cells treated with interleukin-13 (IL-13).