RAS

[Molecular Cancer] Rigosertib monotherapy or in combination therapy with immune checkpoint blockade were investigated using immunocompetent mouse models of BRAFwt and BRAFmut melanoma and analyzed in reference to patient data.

[Communications Biology] Using glioblastoma patient-derived stem cells, researchers identified and characterized a subset of Gal-3high glioblastoma tumors mainly within the mesenchymal subtype that are addicted to Gal-3-mediated macropinocytosis.

[eLife] In addition to impacting stem cell proliferation during damage-induced intestinal regeneration, the role of RAL GTPases impacted on EGFR-dependent tumorigenic growth in the intestine and in human mammary epithelium.

[Experimental & Molecular Medicine] Researchers evaluated the effect of Slit2 on the proliferation and migration of mouse lung epithelial cells and its role in regeneration in an emphysema lung mouse model.

[Cell Reports] Researchers showed that the underlying mechanisms involved the recruitment of phospholipase C-γ1 (PLC-γ1) to a cytoplasmic motif of PD-L1, which enhances PLC-γ1 activation by EGFR.

[Cell Death & Disease] Researchers analyzed the collagen and matrix metalloproteinase 1 (MMP1) expression in Neurofibromatosis 1 cutaneous neurofibroma and found excessive expression of collagen and reduced expression of MMP1.