RAS

[Proceedings of the National Academy of Sciences of the United States of America] Investigators used proximity labeling to identify protein interactors of active KRAS in pancreatic ductal adenocarcinoma (PDAC) cells. We expressed fusions of wild-type (WT) (BirA-KRAS4B), mutant (BirA-KRAS4BG12D), and nontransforming cytosolic double mutant (BirA-KRAS4BG12D/C185S) KRAS with the BirA biotin ligase in murine PDAC cells.

[Cell Death & Disease] Researchers analyzed the collagen and matrix metalloproteinase 1 (MMP1) expression in Neurofibromatosis 1 cutaneous neurofibroma and found excessive expression of collagen and reduced expression of MMP1.

[Prostate Cancer and Prostatic Diseases] Scientists explore the potential mechanisms of SARS-CoV-2 in targeting the prostate gland, leading to exacerbation of benign prostatic hyperplasia (BPH) symptoms and greater risks of BPH complications such as acute urinary retention.

[Nature Communications] Using a multiomics platform and biochemical and molecular studies scientists showed that in pCMML RAS pathway mutations were associated with a unique gene expression profile enriched in mitotic kinases such as polo-like kinase 1.

[Cellular Signalling] The authors explored the PDGF-PDGFR gene expression changes and their involvement in skeletal muscle myogenesis and myogenic fate.

[Scientific Reports] Researchers measured a multidimensional migration phenotype for genetically defined human breast epithelial cell lines that ranged in their in vivo behavior from non-tumorigenic to aggressively metastatic.