RUNX3

[Cell] Scientists developed an in vivo T cell CRISPR screening platform and identified a key mechanism restraining T EFF biology through the ETS family TF, Fli1.

[Cell Reports] Using multiplexed gene regulation with orthogonal CRISPR systems, researchers demonstrated improved neuronal differentiation with concurrent activation and repression of target genes, underscoring the power of CRISPR-based gene regulation for programming complex cellular phenotypes.

[Nature Communications] Investigators describe a viable hypomorphic allele of dnmt1 in zebrafish that caused widespread demethylation of CpG dinucleotides in sperm and somatic tissues.