SHH

[Nature Neuroscience] Researchers identified bidirectional crosstalk between the neural and the vascular compartment of the developing CNS required for oligodendrocyte precursor cell specification.

[Clinical Cancer Research] Scientists investigated how Hedgehog pathway inhibition reprogramed the pancreatic ductal adenocarcinoma microenvironment.

[FEBS Journal] Scientists investigated the interaction between macrophages and fibrosis‐associated alveolar epithelial cells using a bleomycin‐induced mouse pulmonary fibrosis model and a co‐culture system.

[International Journal of Molecular Sciences] Scientists report that miR-506-3p expression was markedly reduced in erlotinib-resistant (ER) cells. They identified Sonic Hedgehog as a novel target of miR-506-3p, aberrantly activated in ER cells.

[Cell Death & Differentiation] To define the mechanisms linking proliferation and apoptotic threshold, researchers examined the effect of conditionally deleting Bcl2l1, the gene that codes the antiapoptotic protein BCL-xL, in cerebellar granule neuron progenitors, and of co-deleting Bcl2l1 homologs, antiapoptotic Mcl-1, or pro-apoptotic Bax.

[Stem Cells] Investigators reprogrammed human synovial fluid‐derived MSCs into induced pluripotent stem cells (iPSCs) using six reprogramming factors and reverted the iPSCs back to MSCs, as an approach to cell rejuvenation.