STAT3

[Cell Death Discovery] Scientists observed that disrupting glioblastoma hyaluronic acid synthesis or blocking HA binding to its receptor CD44 on macrophages increased the proportion of M1 macrophages by upregulating SIRPα in macrophages,

[Neuro-Oncology] Researchers screened a library of drugs either FDA-approved or in clinical trial using a library of patient-derived H3K27M-mutant diffuse midline glioma cell lines with cell viability as the outcome.

[Nature Cell Biology] Researchers developed and applied CellComm to investigate how the aorta–gonad–mesonephros microenvironment dictates hematopoietic stem and progenitor cell emergence.

[Nature Communications] Utilizing single-cell RNA and T cell receptor profiling, researchers showed that irrespective of STAT3 mutation status, T cell large granular lymphocytic leukemia clonotypes were more cytotoxic and exhausted than healthy reactive clonotypes.

[Nature Communications] Utilizing single-cell RNA and T cell receptor profiling, researchers showed that irrespective of STAT3 mutation status, T cell large granular lymphocytic leukemia clonotypes were more cytotoxic and exhausted than healthy reactive clonotypes.

[JCI Insight] The authors demonstrated that mice with intestinal epithelium-specific deletion of Krüppel-like factor 5 (Klf5) developed Th17-dependent colonic inflammation.