STAT3

[Acta Neuropathologica] Investigators identified a previously unrecognized role of the pro-autophagy factor AMBRA1 in regulating medulloblastoma .

[Oncogene] Scientists found that DIF-1 induced phosphorylation of AMPK and Raptor and dephosphorylation of p70S6K in multiple TNBC cell lines.

[British Journal of Pharmacology] Researchers used loss/gain-of-function approaches by gene delivery to determine whether cytokine induced apoptosis inhibitor 1 (CIAPIN1) modulated vascular smooth muscle cell proliferation, migration, and neointima formation, and to define the underlying mechanisms.

[Nature Communications] Cancer-associated fibroblast-activated stromal signaling, interleukin-6/8-JAK2, induced BRD4 phosphorylation at tyrosine 97/98 in colorectal cancer, resulting in BRD4 stabilization due to interaction with the deubiquitinase UCHL3.

[Acta Pharmacologica Sinica] WZ-2-033 significantly inhibited the proliferation, colony survival, migration, and invasion of TNBC cells and gastric cancer cells with aberrant signal transducer and activator of transcription 3 (STAT3) activation.

[Nature Communications] Investigators identified v-maf musculoaponeurotic fibrosarcoma oncogene homolog F (MAFF) as a potent regulator of tumor invasion without affecting cell viability, and demonstrated the oncogenic role of MAFF as an activator of the IL11/STAT3 pathways in breast cancer.